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A Strange Manifestation of Malaria in a Native Nigerian Boy
The protective role of Sickle Cell Trait (SCT) in malaria endemic areas has been proved, and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, while the association with malaria is considered rare. A Nigerian boy was admitted to our ward...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Università Cattolica del Sacro Cuore
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333739/ https://www.ncbi.nlm.nih.gov/pubmed/28293411 http://dx.doi.org/10.4084/MJHID.2017.023 |
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author | Magro, Paola Izzo, Ilaria Saccani, Barbara Casari, Salvatore Caligaris, Silvio Tomasoni, Lina Rachele Matteelli, Alberto Lombardi, Annamaria Meini, Antonella Castelli, Francesco |
author_facet | Magro, Paola Izzo, Ilaria Saccani, Barbara Casari, Salvatore Caligaris, Silvio Tomasoni, Lina Rachele Matteelli, Alberto Lombardi, Annamaria Meini, Antonella Castelli, Francesco |
author_sort | Magro, Paola |
collection | PubMed |
description | The protective role of Sickle Cell Trait (SCT) in malaria endemic areas has been proved, and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, while the association with malaria is considered rare. A Nigerian boy was admitted to our ward after returning from his country of origin, for P. falciparum malaria. He underwent abdominal ultrasound for upper right abdominal pain, showing cholecystitis and multiple splenic lesions suggestive of abscesses. Empiric antibiotic therapy was undertaken. Bartonella, Echinococcus, Entamoeba serologies, blood cultures, Quantiferon test, copro-parasitologic exam were negative; endocarditis was excluded. He underwent further blood exams and abdomen MRI, confirming the presence of signal alterations areas, with radiographic appearance of recent post-infarction outcomes. Hemoglobin electrophoresis showed a percentage of HbS of 40.6% and a diagnosis of SCT was then made. Splenic infarction should be taken into account in patients with malaria and localized abdominal pain. Moreover, diagnosis of SCT should be considered. |
format | Online Article Text |
id | pubmed-5333739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Università Cattolica del Sacro Cuore |
record_format | MEDLINE/PubMed |
spelling | pubmed-53337392017-03-14 A Strange Manifestation of Malaria in a Native Nigerian Boy Magro, Paola Izzo, Ilaria Saccani, Barbara Casari, Salvatore Caligaris, Silvio Tomasoni, Lina Rachele Matteelli, Alberto Lombardi, Annamaria Meini, Antonella Castelli, Francesco Mediterr J Hematol Infect Dis Case Reports The protective role of Sickle Cell Trait (SCT) in malaria endemic areas has been proved, and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, while the association with malaria is considered rare. A Nigerian boy was admitted to our ward after returning from his country of origin, for P. falciparum malaria. He underwent abdominal ultrasound for upper right abdominal pain, showing cholecystitis and multiple splenic lesions suggestive of abscesses. Empiric antibiotic therapy was undertaken. Bartonella, Echinococcus, Entamoeba serologies, blood cultures, Quantiferon test, copro-parasitologic exam were negative; endocarditis was excluded. He underwent further blood exams and abdomen MRI, confirming the presence of signal alterations areas, with radiographic appearance of recent post-infarction outcomes. Hemoglobin electrophoresis showed a percentage of HbS of 40.6% and a diagnosis of SCT was then made. Splenic infarction should be taken into account in patients with malaria and localized abdominal pain. Moreover, diagnosis of SCT should be considered. Università Cattolica del Sacro Cuore 2017-03-01 /pmc/articles/PMC5333739/ /pubmed/28293411 http://dx.doi.org/10.4084/MJHID.2017.023 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Magro, Paola Izzo, Ilaria Saccani, Barbara Casari, Salvatore Caligaris, Silvio Tomasoni, Lina Rachele Matteelli, Alberto Lombardi, Annamaria Meini, Antonella Castelli, Francesco A Strange Manifestation of Malaria in a Native Nigerian Boy |
title | A Strange Manifestation of Malaria in a Native Nigerian Boy |
title_full | A Strange Manifestation of Malaria in a Native Nigerian Boy |
title_fullStr | A Strange Manifestation of Malaria in a Native Nigerian Boy |
title_full_unstemmed | A Strange Manifestation of Malaria in a Native Nigerian Boy |
title_short | A Strange Manifestation of Malaria in a Native Nigerian Boy |
title_sort | strange manifestation of malaria in a native nigerian boy |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333739/ https://www.ncbi.nlm.nih.gov/pubmed/28293411 http://dx.doi.org/10.4084/MJHID.2017.023 |
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