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A new mathematical model of bacterial interactions in two-species oral biofilms

Periodontitis are bacterial inflammatory diseases, where the bacterial biofilms present on the tooth-supporting tissues switch from a healthy state towards a pathogenic state. Among bacterial species involved in the disease, Porphyromonas gingivalis has been shown to induce dysbiosis, and to induce...

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Autores principales: Martin, Bénédicte, Tamanai-Shacoori, Zohreh, Bronsard, Julie, Ginguené, Franck, Meuric, Vincent, Mahé, Fabrice, Bonnaure-Mallet, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333920/
https://www.ncbi.nlm.nih.gov/pubmed/28253369
http://dx.doi.org/10.1371/journal.pone.0173153
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author Martin, Bénédicte
Tamanai-Shacoori, Zohreh
Bronsard, Julie
Ginguené, Franck
Meuric, Vincent
Mahé, Fabrice
Bonnaure-Mallet, Martine
author_facet Martin, Bénédicte
Tamanai-Shacoori, Zohreh
Bronsard, Julie
Ginguené, Franck
Meuric, Vincent
Mahé, Fabrice
Bonnaure-Mallet, Martine
author_sort Martin, Bénédicte
collection PubMed
description Periodontitis are bacterial inflammatory diseases, where the bacterial biofilms present on the tooth-supporting tissues switch from a healthy state towards a pathogenic state. Among bacterial species involved in the disease, Porphyromonas gingivalis has been shown to induce dysbiosis, and to induce virulence of otherwise healthy bacteria like Streptococcus gordonii. During biofilm development, primary colonizers such as S. gordonii first attach to the surface and allow the subsequent adhesion of periodontal pathogens such as P. gingivalis. Interactions between those two bacteria have been extensively studied during the adhesion step of the biofilm. The aim of the study was to understand interactions of both species during the growing phase of the biofilm, for which little knowledge is available, using a mathematical model. This two-species biofilm model was based on a substrate-dependent growth, implemented with damage parameters, and validated thanks to data obtained on experimental biofilms. Three different hypothesis of interactions were proposed and assayed using this model: independence, competition between both bacteria species, or induction of toxicity by one species for the other species. Adequacy between experimental and simulated biofilms were found with the last hypothetic mathematical model. This new mathematical model of two species bacteria biofilms, dependent on different substrates for growing, can be applied to any bacteria species, environmental conditions, or steps of biofilm development. It will be of great interest for exploring bacterial interactions in biofilm conditions.
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spelling pubmed-53339202017-03-10 A new mathematical model of bacterial interactions in two-species oral biofilms Martin, Bénédicte Tamanai-Shacoori, Zohreh Bronsard, Julie Ginguené, Franck Meuric, Vincent Mahé, Fabrice Bonnaure-Mallet, Martine PLoS One Research Article Periodontitis are bacterial inflammatory diseases, where the bacterial biofilms present on the tooth-supporting tissues switch from a healthy state towards a pathogenic state. Among bacterial species involved in the disease, Porphyromonas gingivalis has been shown to induce dysbiosis, and to induce virulence of otherwise healthy bacteria like Streptococcus gordonii. During biofilm development, primary colonizers such as S. gordonii first attach to the surface and allow the subsequent adhesion of periodontal pathogens such as P. gingivalis. Interactions between those two bacteria have been extensively studied during the adhesion step of the biofilm. The aim of the study was to understand interactions of both species during the growing phase of the biofilm, for which little knowledge is available, using a mathematical model. This two-species biofilm model was based on a substrate-dependent growth, implemented with damage parameters, and validated thanks to data obtained on experimental biofilms. Three different hypothesis of interactions were proposed and assayed using this model: independence, competition between both bacteria species, or induction of toxicity by one species for the other species. Adequacy between experimental and simulated biofilms were found with the last hypothetic mathematical model. This new mathematical model of two species bacteria biofilms, dependent on different substrates for growing, can be applied to any bacteria species, environmental conditions, or steps of biofilm development. It will be of great interest for exploring bacterial interactions in biofilm conditions. Public Library of Science 2017-03-02 /pmc/articles/PMC5333920/ /pubmed/28253369 http://dx.doi.org/10.1371/journal.pone.0173153 Text en © 2017 Martin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Martin, Bénédicte
Tamanai-Shacoori, Zohreh
Bronsard, Julie
Ginguené, Franck
Meuric, Vincent
Mahé, Fabrice
Bonnaure-Mallet, Martine
A new mathematical model of bacterial interactions in two-species oral biofilms
title A new mathematical model of bacterial interactions in two-species oral biofilms
title_full A new mathematical model of bacterial interactions in two-species oral biofilms
title_fullStr A new mathematical model of bacterial interactions in two-species oral biofilms
title_full_unstemmed A new mathematical model of bacterial interactions in two-species oral biofilms
title_short A new mathematical model of bacterial interactions in two-species oral biofilms
title_sort new mathematical model of bacterial interactions in two-species oral biofilms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333920/
https://www.ncbi.nlm.nih.gov/pubmed/28253369
http://dx.doi.org/10.1371/journal.pone.0173153
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