The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells

Oxadiazines are heterocyclic compounds containing N-N-O or N-N-C-O system within a six membered ring. These structures have been up to now exclusively prepared via organic synthesis. Here, we report the discovery of a natural oxadiazine nocuolin A (NoA) that has a unique structure based on 1,2,3-oxa...

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Detalles Bibliográficos
Autores principales: Voráčová, Kateřina, Hájek, Jan, Mareš, Jan, Urajová, Petra, Kuzma, Marek, Cheel, José, Villunger, Andreas, Kapuscik, Alexandra, Bally, Marcel, Novák, Petr, Kabeláč, Martin, Krumschnabel, Gerhard, Lukeš, Martin, Voloshko, Ludmila, Kopecký, Jiří, Hrouzek, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333925/
https://www.ncbi.nlm.nih.gov/pubmed/28253280
http://dx.doi.org/10.1371/journal.pone.0172850

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