Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity

Human cells have twenty-three pairs of chromosomes but in cancer, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ECDNA), whose frequency and functional significance are not understood(1–4). We performed whole genome sequencing, structural modeling and cytogenetic analyses...

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Detalles Bibliográficos
Autores principales: Turner, Kristen M., Deshpande, Viraj, Beyter, Doruk, Koga, Tomoyuki, Rusert, Jessica, Lee, Catherine, Li, Bin, Arden, Karen, Ren, Bing, Nathanson, David A., Kornblum, Harley I., Taylor, Michael D., Kaushal, Sharmeela, Cavenee, Webster K., Wechsler-Reya, Robert, Furnari, Frank B., Vandenberg, Scott R., Rao, P. Nagesh, Wahl, Geoffrey M., Bafna, Vineet, Mischel, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334176/
https://www.ncbi.nlm.nih.gov/pubmed/28178237
http://dx.doi.org/10.1038/nature21356

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