Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling

Glucose‐ or insulin resistance‐mediated β‐cell replication serves as a useful physiological model of β‐cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β‐cell proliferation induced by glucose stimu...

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Detalles Bibliográficos
Autores principales: Shirakawa, Jun, Terauchi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334311/
https://www.ncbi.nlm.nih.gov/pubmed/27479547
http://dx.doi.org/10.1111/jdi.12558
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author Shirakawa, Jun
Terauchi, Yasuo
author_facet Shirakawa, Jun
Terauchi, Yasuo
author_sort Shirakawa, Jun
collection PubMed
description Glucose‐ or insulin resistance‐mediated β‐cell replication serves as a useful physiological model of β‐cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β‐cell proliferation induced by glucose stimulation or high‐fat diet‐feeding. [Image: see text]
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spelling pubmed-53343112017-03-06 Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling Shirakawa, Jun Terauchi, Yasuo J Diabetes Investig Commentaries Glucose‐ or insulin resistance‐mediated β‐cell replication serves as a useful physiological model of β‐cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β‐cell proliferation induced by glucose stimulation or high‐fat diet‐feeding. [Image: see text] John Wiley and Sons Inc. 2016-09-11 2017-03 /pmc/articles/PMC5334311/ /pubmed/27479547 http://dx.doi.org/10.1111/jdi.12558 Text en © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentaries
Shirakawa, Jun
Terauchi, Yasuo
Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
title Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
title_full Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
title_fullStr Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
title_full_unstemmed Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
title_short Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
title_sort glucose‐ or insulin resistance‐mediated β‐cell replication: pkcζ integrates the proliferative signaling
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334311/
https://www.ncbi.nlm.nih.gov/pubmed/27479547
http://dx.doi.org/10.1111/jdi.12558
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AT terauchiyasuo glucoseorinsulinresistancemediatedbcellreplicationpkczintegratestheproliferativesignaling

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