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Integrating functional genomics to accelerate mechanistic personalized medicine
The advent of deep sequencing technologies has resulted in the deciphering of tremendous amounts of genetic information. These data have led to major discoveries, and many anecdotes now exist of individual patients whose clinical outcomes have benefited from novel, genetically guided therapeutic str...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334473/ https://www.ncbi.nlm.nih.gov/pubmed/28299357 http://dx.doi.org/10.1101/mcs.a001370 |
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author | Tyner, Jeffrey W. |
author_facet | Tyner, Jeffrey W. |
author_sort | Tyner, Jeffrey W. |
collection | PubMed |
description | The advent of deep sequencing technologies has resulted in the deciphering of tremendous amounts of genetic information. These data have led to major discoveries, and many anecdotes now exist of individual patients whose clinical outcomes have benefited from novel, genetically guided therapeutic strategies. However, the majority of genetic events in cancer are currently undrugged, leading to a biological gap between understanding of tumor genetic etiology and translation to improved clinical approaches. Functional screening has made tremendous strides in recent years with the development of new experimental approaches to studying ex vivo and in vivo drug sensitivity. Numerous discoveries and anecdotes also exist for translation of functional screening into novel clinical strategies; however, the current clinical application of functional screening remains largely confined to small clinical trials at specific academic centers. The intersection between genomic and functional approaches represents an ideal modality to accelerate our understanding of drug sensitivities as they relate to specific genetic events and further understand the full mechanisms underlying drug sensitivity patterns. |
format | Online Article Text |
id | pubmed-5334473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53344732017-03-15 Integrating functional genomics to accelerate mechanistic personalized medicine Tyner, Jeffrey W. Cold Spring Harb Mol Case Stud Commentary The advent of deep sequencing technologies has resulted in the deciphering of tremendous amounts of genetic information. These data have led to major discoveries, and many anecdotes now exist of individual patients whose clinical outcomes have benefited from novel, genetically guided therapeutic strategies. However, the majority of genetic events in cancer are currently undrugged, leading to a biological gap between understanding of tumor genetic etiology and translation to improved clinical approaches. Functional screening has made tremendous strides in recent years with the development of new experimental approaches to studying ex vivo and in vivo drug sensitivity. Numerous discoveries and anecdotes also exist for translation of functional screening into novel clinical strategies; however, the current clinical application of functional screening remains largely confined to small clinical trials at specific academic centers. The intersection between genomic and functional approaches represents an ideal modality to accelerate our understanding of drug sensitivities as they relate to specific genetic events and further understand the full mechanisms underlying drug sensitivity patterns. Cold Spring Harbor Laboratory Press 2017-03 /pmc/articles/PMC5334473/ /pubmed/28299357 http://dx.doi.org/10.1101/mcs.a001370 Text en © 2017 Tyner; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited. |
spellingShingle | Commentary Tyner, Jeffrey W. Integrating functional genomics to accelerate mechanistic personalized medicine |
title | Integrating functional genomics to accelerate mechanistic personalized medicine |
title_full | Integrating functional genomics to accelerate mechanistic personalized medicine |
title_fullStr | Integrating functional genomics to accelerate mechanistic personalized medicine |
title_full_unstemmed | Integrating functional genomics to accelerate mechanistic personalized medicine |
title_short | Integrating functional genomics to accelerate mechanistic personalized medicine |
title_sort | integrating functional genomics to accelerate mechanistic personalized medicine |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334473/ https://www.ncbi.nlm.nih.gov/pubmed/28299357 http://dx.doi.org/10.1101/mcs.a001370 |
work_keys_str_mv | AT tynerjeffreyw integratingfunctionalgenomicstoacceleratemechanisticpersonalizedmedicine |