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Phenotypic characteristics of aged CD4(+) CD28(null) T lymphocytes are determined by changes in the whole‐genome DNA methylation pattern
Aging is associated with a progressive loss of the CD28 costimulatory molecule in CD4(+) lymphocytes (CD28(null) T cells), which is accompanied by the acquisition of new biological and functional properties that give rise to an impaired immune response. The regulatory mechanisms that govern the appe...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334526/ https://www.ncbi.nlm.nih.gov/pubmed/28026094 http://dx.doi.org/10.1111/acel.12552 |