The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Age‐related cataractogenesis is associated with disulfide‐linked high molecular weight (HMW) crystallin aggregates. We recently found that the lens crystallin disulfidome was evolutionarily conserved in human and glutathione‐depleted mouse (LEGSKO) cataracts and that it could be mimicked by oxidatio...

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Detalles Bibliográficos
Autores principales: Wang, Benlian, Hom, Grant, Zhou, Sheng, Guo, Minfei, Li, Binbin, Yang, Jing, Monnier, Vincent M., Fan, Xingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334568/
https://www.ncbi.nlm.nih.gov/pubmed/28177569
http://dx.doi.org/10.1111/acel.12548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334568/
https://www.ncbi.nlm.nih.gov/pubmed/28177569
http://dx.doi.org/10.1111/acel.12548

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