Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025

Four new compounds (1–4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configur...

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Autores principales: Xu, Xinya, Zhang, Xiaoyong, Nong, Xuhua, Wang, Jie, Qi, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334623/
https://www.ncbi.nlm.nih.gov/pubmed/28218640
http://dx.doi.org/10.3390/md15020043
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author Xu, Xinya
Zhang, Xiaoyong
Nong, Xuhua
Wang, Jie
Qi, Shuhua
author_facet Xu, Xinya
Zhang, Xiaoyong
Nong, Xuhua
Wang, Jie
Qi, Shuhua
author_sort Xu, Xinya
collection PubMed
description Four new compounds (1–4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC(50) value of 15.6 μM. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC(50) values of 13.7 and 22.6 μM, respectively. The NMR data of 6, 8, and 9 were assigned for the first time.
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spelling pubmed-53346232017-03-16 Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025 Xu, Xinya Zhang, Xiaoyong Nong, Xuhua Wang, Jie Qi, Shuhua Mar Drugs Article Four new compounds (1–4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC(50) value of 15.6 μM. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC(50) values of 13.7 and 22.6 μM, respectively. The NMR data of 6, 8, and 9 were assigned for the first time. MDPI 2017-02-17 /pmc/articles/PMC5334623/ /pubmed/28218640 http://dx.doi.org/10.3390/md15020043 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xinya
Zhang, Xiaoyong
Nong, Xuhua
Wang, Jie
Qi, Shuhua
Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
title Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
title_full Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
title_fullStr Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
title_full_unstemmed Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
title_short Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025
title_sort brevianamides and mycophenolic acid derivatives from the deep-sea-derived fungus penicillium brevicompactum dffscs025
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334623/
https://www.ncbi.nlm.nih.gov/pubmed/28218640
http://dx.doi.org/10.3390/md15020043
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