Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

[Image: see text] Driven by the ever-increasing pace of drug discovery and the need to push the boundaries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained bioisosteres such as bicyclo[1.1.1]pentane, azetidine, and cyclobutane to modify their lead compounds....

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Detalles Bibliográficos
Autores principales: Lopchuk, Justin M., Fjelbye, Kasper, Kawamata, Yu, Malins, Lara R., Pan, Chung-Mao, Gianatassio, Ryan, Wang, Jie, Prieto, Liher, Bradow, James, Brandt, Thomas A., Collins, Michael R., Elleraas, Jeff, Ewanicki, Jason, Farrell, William, Fadeyi, Olugbeminiyi O., Gallego, Gary M., Mousseau, James J., Oliver, Robert, Sach, Neal W., Smith, Jason K., Spangler, Jillian E., Zhu, Huichin, Zhu, Jinjiang, Baran, Phil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334783/
https://www.ncbi.nlm.nih.gov/pubmed/28140573
http://dx.doi.org/10.1021/jacs.6b13229

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