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Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly
This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over. Psychological distress was assessed using the University of California at Los Angeles Lone...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335556/ https://www.ncbi.nlm.nih.gov/pubmed/28256594 http://dx.doi.org/10.1038/srep43816 |
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author | Duan, Dandan Dong, Yuanli Zhang, Hua Zhao, Yingxin Diao, Yutao Cui, Yi Wang, Juan Chai, Qiang Liu, Zhendong |
author_facet | Duan, Dandan Dong, Yuanli Zhang, Hua Zhao, Yingxin Diao, Yutao Cui, Yi Wang, Juan Chai, Qiang Liu, Zhendong |
author_sort | Duan, Dandan |
collection | PubMed |
description | This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over. Psychological distress was assessed using the University of California at Los Angeles Loneliness Scale (UCLA-LS) and Geriatric Depression Scale (GDS) Short-Form. Cognitive function was evaluated using the MMSE and MoCA. White matter hyperintensities (WMH) were assessed using magnetic resonance imaging. After 5.2-year follow-up, the reductions in MMSE and MoCA scores and the increases in periventricular (P)WMH, deep (D)WMH, and total WMH volumes in the empty-nest elderly were greater than those in the non-empty-nest elderly (P < 0.05). The reduced MMSE and MoCA scores and increased volumes of PWMH and total WMH in the empty-nest elderly living alone were greater than those in the empty-nest elderly living with a spouse (P < 0.05). UCLA-LS and GDS scores were significantly and independently associated with reduced MMSE and MoCA scores and the increased volumes of PWMH, DWMH, and total WMH. The results indicate that empty-nest-related psychological distress is associated with progression of WMLs and cognitive impairment in the elderly. |
format | Online Article Text |
id | pubmed-5335556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53355562017-03-07 Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly Duan, Dandan Dong, Yuanli Zhang, Hua Zhao, Yingxin Diao, Yutao Cui, Yi Wang, Juan Chai, Qiang Liu, Zhendong Sci Rep Article This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over. Psychological distress was assessed using the University of California at Los Angeles Loneliness Scale (UCLA-LS) and Geriatric Depression Scale (GDS) Short-Form. Cognitive function was evaluated using the MMSE and MoCA. White matter hyperintensities (WMH) were assessed using magnetic resonance imaging. After 5.2-year follow-up, the reductions in MMSE and MoCA scores and the increases in periventricular (P)WMH, deep (D)WMH, and total WMH volumes in the empty-nest elderly were greater than those in the non-empty-nest elderly (P < 0.05). The reduced MMSE and MoCA scores and increased volumes of PWMH and total WMH in the empty-nest elderly living alone were greater than those in the empty-nest elderly living with a spouse (P < 0.05). UCLA-LS and GDS scores were significantly and independently associated with reduced MMSE and MoCA scores and the increased volumes of PWMH, DWMH, and total WMH. The results indicate that empty-nest-related psychological distress is associated with progression of WMLs and cognitive impairment in the elderly. Nature Publishing Group 2017-03-03 /pmc/articles/PMC5335556/ /pubmed/28256594 http://dx.doi.org/10.1038/srep43816 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Duan, Dandan Dong, Yuanli Zhang, Hua Zhao, Yingxin Diao, Yutao Cui, Yi Wang, Juan Chai, Qiang Liu, Zhendong Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
title | Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
title_full | Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
title_fullStr | Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
title_full_unstemmed | Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
title_short | Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
title_sort | empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335556/ https://www.ncbi.nlm.nih.gov/pubmed/28256594 http://dx.doi.org/10.1038/srep43816 |
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