Cargando…
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α(2)δ-1 subunit
Voltage-gated Ca(2+) (Ca(V)) channels consist of a pore-forming α1 subunit, which determines the main functional and pharmacological attributes of the channel. The Ca(V)1 and Ca(V)2 channels are associated with auxiliary β- and α(2)δ-subunits. The molecular mechanisms involved in α(2)δ subunit traff...
Autores principales: | Kadurin, Ivan, Rothwell, Simon W., Lana, Beatrice, Nieto-Rostro, Manuela, Dolphin, Annette C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335561/ https://www.ncbi.nlm.nih.gov/pubmed/28256585 http://dx.doi.org/10.1038/srep43802 |
Ejemplares similares
-
Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α(2)δ-1-subunit but does not interact with α(2)δ-1 on the cell-surface when co-expressed
por: Lana, Beatrice, et al.
Publicado: (2016) -
Proteolytic maturation of α(2)δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels
por: Kadurin, Ivan, et al.
Publicado: (2016) -
Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo
por: Nieto-Rostro, Manuela, et al.
Publicado: (2018) -
ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α(2)δ Subunits, and Enables Calcium Current Enhancement
por: Kadurin, Ivan, et al.
Publicado: (2022) -
Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α(2)δ-1 but not α(2)δ-3
por: Meyer, James O., et al.
Publicado: (2021)