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Biophysical studies suggest a new structural arrangement of crotoxin and provide insights into its toxic mechanism

Crotoxin (CTX) is the main neurotoxin found in Crotalus durissus rattlesnake venoms being composed by a nontoxic and non-enzymatic component (CA) and a toxic phospholipase A(2) (CB). Previous crystallographic structures of CTX and CB provided relevant insights: (i) CTX structure showed a 1:1 molecul...

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Detalles Bibliográficos
Autores principales:	Fernandes, Carlos A. H., Pazin, Wallance M., Dreyer, Thiago R., Bicev, Renata N., Cavalcante, Walter L. G., Fortes-Dias, Consuelo L., Ito, Amando S., Oliveira, Cristiano L. P., Fernandez, Roberto Morato, Fontes, Marcos R. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335569/ https://www.ncbi.nlm.nih.gov/pubmed/28256632 http://dx.doi.org/10.1038/srep43885

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