Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products

An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh(3)-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtain...

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Autores principales: Jia, Nan-Nan, Tian, Xin-Chuan, Qu, Xiao-Xia, Chen, Xing-Xiu, Cao, Ya-Nan, Yao, Yun-Xin, Gao, Feng, Zhou, Xian-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335610/
https://www.ncbi.nlm.nih.gov/pubmed/28256577
http://dx.doi.org/10.1038/srep43758
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author Jia, Nan-Nan
Tian, Xin-Chuan
Qu, Xiao-Xia
Chen, Xing-Xiu
Cao, Ya-Nan
Yao, Yun-Xin
Gao, Feng
Zhou, Xian-Li
author_facet Jia, Nan-Nan
Tian, Xin-Chuan
Qu, Xiao-Xia
Chen, Xing-Xiu
Cao, Ya-Nan
Yao, Yun-Xin
Gao, Feng
Zhou, Xian-Li
author_sort Jia, Nan-Nan
collection PubMed
description An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh(3)-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtained 2-aryl benzoxazoles (benzoimidazoles) was also evaluated and 1-methyl-2-(naphthalen-1-yl)benzoimidazole showed potential cytotoxicity.
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spelling pubmed-53356102017-03-07 Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products Jia, Nan-Nan Tian, Xin-Chuan Qu, Xiao-Xia Chen, Xing-Xiu Cao, Ya-Nan Yao, Yun-Xin Gao, Feng Zhou, Xian-Li Sci Rep Article An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh(3)-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtained 2-aryl benzoxazoles (benzoimidazoles) was also evaluated and 1-methyl-2-(naphthalen-1-yl)benzoimidazole showed potential cytotoxicity. Nature Publishing Group 2017-03-03 /pmc/articles/PMC5335610/ /pubmed/28256577 http://dx.doi.org/10.1038/srep43758 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Jia, Nan-Nan
Tian, Xin-Chuan
Qu, Xiao-Xia
Chen, Xing-Xiu
Cao, Ya-Nan
Yao, Yun-Xin
Gao, Feng
Zhou, Xian-Li
Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products
title Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products
title_full Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products
title_fullStr Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products
title_full_unstemmed Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products
title_short Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products
title_sort copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides and cytotoxicity of products
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335610/
https://www.ncbi.nlm.nih.gov/pubmed/28256577
http://dx.doi.org/10.1038/srep43758
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