Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

We have used a computational approach to identify anti-fibrotic therapies by querying a transcriptome. A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against a transcriptomic database that quantifies changes in gene exp...

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Detalles Bibliográficos
Autores principales: Hicks, Daniel F., Goossens, Nicolas, Blas-García, Ana, Tsuchida, Takuma, Wooden, Benjamin, Wallace, Michael C., Nieto, Natalia, Lade, Abigale, Redhead, Benjamin, Cederbaum, Arthur I, Dudley, Joel T., Fuchs, Bryan C., Lee, Youngmin A., Hoshida, Yujin, Friedman, Scott L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335661/
https://www.ncbi.nlm.nih.gov/pubmed/28256512
http://dx.doi.org/10.1038/srep42563

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