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Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity

The incidence of benign prostatic hyperplasia (BPH) is increasing among obese individuals, but few studies have fully explained the underlying mechanisms. We aimed to elucidate the relationship between obesity and BPH. Herein, we show that in prostatic epithelial and stromal cells, adiponectin exert...

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Autores principales: Fu, Shi, Xu, Huan, Gu, Meng, Liu, Chong, Wang, Qiong, Wan, Xiang, Chen, Yanbo, Chen, Qi, Peng, Yubing, Cai, Zhikang, Zhou, Juan, Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335662/
https://www.ncbi.nlm.nih.gov/pubmed/28256562
http://dx.doi.org/10.1038/srep43771
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author Fu, Shi
Xu, Huan
Gu, Meng
Liu, Chong
Wang, Qiong
Wan, Xiang
Chen, Yanbo
Chen, Qi
Peng, Yubing
Cai, Zhikang
Zhou, Juan
Wang, Zhong
author_facet Fu, Shi
Xu, Huan
Gu, Meng
Liu, Chong
Wang, Qiong
Wan, Xiang
Chen, Yanbo
Chen, Qi
Peng, Yubing
Cai, Zhikang
Zhou, Juan
Wang, Zhong
author_sort Fu, Shi
collection PubMed
description The incidence of benign prostatic hyperplasia (BPH) is increasing among obese individuals, but few studies have fully explained the underlying mechanisms. We aimed to elucidate the relationship between obesity and BPH. Herein, we show that in prostatic epithelial and stromal cells, adiponectin exerts multifunctional effects including anti-proliferation, blocking of G1/S-phase progression and the promotion of apoptosis via inhibiting the MEK-ERK-p90RSK axis. Furthermore, we found that a high-fat diet (HFD) led to adiponectin deficiency and microscopic BPH in a mouse model of obesity. And an adiponectin supplement protected the obese mice from microscopic BPH. The present study provides evidence that adiponectin is a protective regulator in the development and progression of BPH and that adiponectin deficiency causally links BPH with obesity.
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spelling pubmed-53356622017-03-07 Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity Fu, Shi Xu, Huan Gu, Meng Liu, Chong Wang, Qiong Wan, Xiang Chen, Yanbo Chen, Qi Peng, Yubing Cai, Zhikang Zhou, Juan Wang, Zhong Sci Rep Article The incidence of benign prostatic hyperplasia (BPH) is increasing among obese individuals, but few studies have fully explained the underlying mechanisms. We aimed to elucidate the relationship between obesity and BPH. Herein, we show that in prostatic epithelial and stromal cells, adiponectin exerts multifunctional effects including anti-proliferation, blocking of G1/S-phase progression and the promotion of apoptosis via inhibiting the MEK-ERK-p90RSK axis. Furthermore, we found that a high-fat diet (HFD) led to adiponectin deficiency and microscopic BPH in a mouse model of obesity. And an adiponectin supplement protected the obese mice from microscopic BPH. The present study provides evidence that adiponectin is a protective regulator in the development and progression of BPH and that adiponectin deficiency causally links BPH with obesity. Nature Publishing Group 2017-03-03 /pmc/articles/PMC5335662/ /pubmed/28256562 http://dx.doi.org/10.1038/srep43771 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Fu, Shi
Xu, Huan
Gu, Meng
Liu, Chong
Wang, Qiong
Wan, Xiang
Chen, Yanbo
Chen, Qi
Peng, Yubing
Cai, Zhikang
Zhou, Juan
Wang, Zhong
Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
title Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
title_full Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
title_fullStr Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
title_full_unstemmed Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
title_short Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
title_sort adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335662/
https://www.ncbi.nlm.nih.gov/pubmed/28256562
http://dx.doi.org/10.1038/srep43771
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