P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1(G93A) amyotrophic lateral sclerosis mice

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterised by the accumulation of aggregated proteins, microglia activation and motor neuron loss. The mechanisms underlying neurodegeneration and disease progression in ALS are unknown, but the ATP...

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Detalles Bibliográficos
Autores principales: Bartlett, Rachael, Sluyter, Vanessa, Watson, Debbie, Sluyter, Ronald, Yerbury, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335685/
https://www.ncbi.nlm.nih.gov/pubmed/28265522
http://dx.doi.org/10.7717/peerj.3064

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