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Computed tomography derived bone density measurement in the diabetic foot
BACKGROUND: The accurate and reliable measurement of foot bone density is challenging and there is currently no gold standard technique. Such measurement is particularly valuable in populations at risk of foot bone pathology such as in those with long term diabetes. With research and development, co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335776/ https://www.ncbi.nlm.nih.gov/pubmed/28270861 http://dx.doi.org/10.1186/s13047-017-0192-7 |
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author | Barwick, Alex Tessier, John Mirow, James de Jonge, Xanne Janse Chuter, Vivienne |
author_facet | Barwick, Alex Tessier, John Mirow, James de Jonge, Xanne Janse Chuter, Vivienne |
author_sort | Barwick, Alex |
collection | PubMed |
description | BACKGROUND: The accurate and reliable measurement of foot bone density is challenging and there is currently no gold standard technique. Such measurement is particularly valuable in populations at risk of foot bone pathology such as in those with long term diabetes. With research and development, computed tomography may prove to be a useful tool for this assessment. The aim of this study was to establish the reliability of a novel method of foot bone density measurement in people with diabetes using computed tomography. METHODS: Ten feet in people with diabetes were scanned with computed tomography twice with repositioning. Bone density (in Hounsfield units) was assessed in the trabecular and cortical bone in all tarsals and metatarsals. Reliability was assessed with intra-class correlation coefficients (95% confidence intervals), limits of agreement and standard error of measurement. RESULTS: The reliability of the trabecular density of most bones was excellent with intra-class correlation coefficients ranging from 0.68 to 0.91. Additionally, cortical bone density showed fair to good reliability at the talus (0.52), calcaneus (0.59), navicular (0.70), cuboid (0.69), intermediate cuneiform (0.46) and first metatarsal (0.61). CONCLUSIONS: The study established the reliability of a practical method of assessing the trabecular and cortical foot bone density using computed tomography scanning. This methodology may be useful in the investigation of foot bone disease occurring in diabetes and its early diagnosis, intervention and assessment of treatment efficacy. Further development of this method is warranted. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13047-017-0192-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5335776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53357762017-03-07 Computed tomography derived bone density measurement in the diabetic foot Barwick, Alex Tessier, John Mirow, James de Jonge, Xanne Janse Chuter, Vivienne J Foot Ankle Res Methodology BACKGROUND: The accurate and reliable measurement of foot bone density is challenging and there is currently no gold standard technique. Such measurement is particularly valuable in populations at risk of foot bone pathology such as in those with long term diabetes. With research and development, computed tomography may prove to be a useful tool for this assessment. The aim of this study was to establish the reliability of a novel method of foot bone density measurement in people with diabetes using computed tomography. METHODS: Ten feet in people with diabetes were scanned with computed tomography twice with repositioning. Bone density (in Hounsfield units) was assessed in the trabecular and cortical bone in all tarsals and metatarsals. Reliability was assessed with intra-class correlation coefficients (95% confidence intervals), limits of agreement and standard error of measurement. RESULTS: The reliability of the trabecular density of most bones was excellent with intra-class correlation coefficients ranging from 0.68 to 0.91. Additionally, cortical bone density showed fair to good reliability at the talus (0.52), calcaneus (0.59), navicular (0.70), cuboid (0.69), intermediate cuneiform (0.46) and first metatarsal (0.61). CONCLUSIONS: The study established the reliability of a practical method of assessing the trabecular and cortical foot bone density using computed tomography scanning. This methodology may be useful in the investigation of foot bone disease occurring in diabetes and its early diagnosis, intervention and assessment of treatment efficacy. Further development of this method is warranted. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13047-017-0192-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-03-03 /pmc/articles/PMC5335776/ /pubmed/28270861 http://dx.doi.org/10.1186/s13047-017-0192-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Methodology Barwick, Alex Tessier, John Mirow, James de Jonge, Xanne Janse Chuter, Vivienne Computed tomography derived bone density measurement in the diabetic foot |
title | Computed tomography derived bone density measurement in the diabetic foot |
title_full | Computed tomography derived bone density measurement in the diabetic foot |
title_fullStr | Computed tomography derived bone density measurement in the diabetic foot |
title_full_unstemmed | Computed tomography derived bone density measurement in the diabetic foot |
title_short | Computed tomography derived bone density measurement in the diabetic foot |
title_sort | computed tomography derived bone density measurement in the diabetic foot |
topic | Methodology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335776/ https://www.ncbi.nlm.nih.gov/pubmed/28270861 http://dx.doi.org/10.1186/s13047-017-0192-7 |
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