Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

Heterozygous somatic mutations affecting the spliceosome gene SF3B1 drive age-related clonal hematopoiesis, myelodysplastic syndromes (MDS) and other neoplasms. To study their role in such disorders, we generated knock-in mice with hematopoietic-specific expression of Sf3b1-K700E, the commonest type...

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Detalles Bibliográficos
Autores principales: Mupo, A, Seiler, M, Sathiaseelan, V, Pance, A, Yang, Y, Agrawal, A A, Iorio, F, Bautista, R, Pacharne, S, Tzelepis, K, Manes, N, Wright, P, Papaemmanuil, E, Kent, D G, Campbell, P C, Buonamici, S, Bolli, N, Vassiliou, G S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336192/
https://www.ncbi.nlm.nih.gov/pubmed/27604819
http://dx.doi.org/10.1038/leu.2016.251

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