The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanis...

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Detalles Bibliográficos
Autores principales: de Oliveira, Rita Machado, Vicente Miranda, Hugo, Francelle, Laetitia, Pinho, Raquel, Szegö, Éva M., Martinho, Renato, Munari, Francesca, Lázaro, Diana F., Moniot, Sébastien, Guerreiro, Patrícia, Fonseca, Luis, Marijanovic, Zrinka, Antas, Pedro, Gerhardt, Ellen, Enguita, Francisco Javier, Fauvet, Bruno, Penque, Deborah, Pais, Teresa Faria, Tong, Qiang, Becker, Stefan, Kügler, Sebastian, Lashuel, Hilal Ahmed, Steegborn, Clemens, Zweckstetter, Markus, Outeiro, Tiago Fleming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336201/
https://www.ncbi.nlm.nih.gov/pubmed/28257421
http://dx.doi.org/10.1371/journal.pbio.2000374

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