Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo

Mammalian target of rapamycin (mTOR)in renal cell carcinoma (RCC) represents a valuable oncotarget for treatment. We here tested the potential anti-RCC activity by a novel mTOR kinase inhibitor WYE-687in vitro and in vivo.WYE-687 was cytotoxic and anti-proliferative to established RCC cell lines (78...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Xiao-dong, Gu, Dong-hua, Mao, Jia-Hui, Zhu, Hua, Chen, Xinfeng, Zheng, Bing, Shan, Yuxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336203/
https://www.ncbi.nlm.nih.gov/pubmed/28257457
http://dx.doi.org/10.1371/journal.pone.0172555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336203/
https://www.ncbi.nlm.nih.gov/pubmed/28257457
http://dx.doi.org/10.1371/journal.pone.0172555

Ejemplares similares