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The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection

Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America and many countries of the temperate Northern Hemisphere. It is associated with local and systemic manifestations and has persistent post-treatment health complications in some individuals. Innate and acqu...

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Detalles Bibliográficos
Autor principal: Badawi, Alaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336413/
https://www.ncbi.nlm.nih.gov/pubmed/27900646
http://dx.doi.org/10.1007/s40121-016-0138-6
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author Badawi, Alaa
author_facet Badawi, Alaa
author_sort Badawi, Alaa
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description Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America and many countries of the temperate Northern Hemisphere. It is associated with local and systemic manifestations and has persistent post-treatment health complications in some individuals. Innate and acquired immunity-related inflammation is likely to play a critical role in both host defense against Borrelia burgdorferi and disease severity. Large-scale analytical approaches to quantify gene expression (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in LB have recently emerged with a potential to advance the development of disease biomarkers in early, disseminated and posttreatment disease stages. These technologies may permit defining the disease stage and facilitate its early detection to improve diagnosis. They will also likely allow elucidating the underlying molecular pathways to aid in identifying molecular targets for therapy. This article reviews the findings within the field of omics relevant to LB and its prospective utility in developing an array of biomarkers that can be employed in LB diagnosis and detection particularly at the early disease stages.
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spelling pubmed-53364132017-03-16 The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection Badawi, Alaa Infect Dis Ther Review Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America and many countries of the temperate Northern Hemisphere. It is associated with local and systemic manifestations and has persistent post-treatment health complications in some individuals. Innate and acquired immunity-related inflammation is likely to play a critical role in both host defense against Borrelia burgdorferi and disease severity. Large-scale analytical approaches to quantify gene expression (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in LB have recently emerged with a potential to advance the development of disease biomarkers in early, disseminated and posttreatment disease stages. These technologies may permit defining the disease stage and facilitate its early detection to improve diagnosis. They will also likely allow elucidating the underlying molecular pathways to aid in identifying molecular targets for therapy. This article reviews the findings within the field of omics relevant to LB and its prospective utility in developing an array of biomarkers that can be employed in LB diagnosis and detection particularly at the early disease stages. Springer Healthcare 2016-11-29 2017-03 /pmc/articles/PMC5336413/ /pubmed/27900646 http://dx.doi.org/10.1007/s40121-016-0138-6 Text en © The Author(s) 2016 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Badawi, Alaa
The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
title The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
title_full The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
title_fullStr The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
title_full_unstemmed The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
title_short The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
title_sort potential of omics technologies in lyme disease biomarker discovery and early detection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336413/
https://www.ncbi.nlm.nih.gov/pubmed/27900646
http://dx.doi.org/10.1007/s40121-016-0138-6
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