PK/PD Target Attainment With Ceftolozane/Tazobactam Using Monte Carlo Simulation in Patients With Various Degrees of Renal Function, Including Augmented Renal Clearance and End-Stage Renal Disease

INTRODUCTION: Ceftolozane/tazobactam is an antibacterial agent with potent in vitro activity against Gram-negative pathogens, including many extended-spectrum β-lactamase-producing Enterobacteriaceae and drug-resistant Pseudomonas aeruginosa. Because ceftolozane/tazobactam is primarily excreted rena...

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Detalles Bibliográficos
Autores principales: Xiao, Alan J., Caro, Luzelena, Popejoy, Myra W., Huntington, Jennifer A., Kullar, Ravina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336418/
https://www.ncbi.nlm.nih.gov/pubmed/28013453
http://dx.doi.org/10.1007/s40121-016-0143-9

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