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Structural basis of Ca(2+)/pH dual regulation of the endolysosomal TRPML1 channel
Organellar ion channels are essential for cell physiology. Their activities are often regulated by Ca(2+) and H(+), which are concentrated in many organelles. Here we report a novel structural element critical for Ca(2+)/pH dual regulation of TRPML1, a Ca(2+) release channel crucial for endolysosoma...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336481/ https://www.ncbi.nlm.nih.gov/pubmed/28112729 http://dx.doi.org/10.1038/nsmb.3362 |