Mechanism and Timing of Mcm2–7 Ring Closure During DNA Replication Origin Licensing

Opening and closing of two ring-shaped Mcm2–7 DNA helicases is necessary to license eukaryotic origins of replication although the mechanisms controlling these events are unclear. The origin-recognition complex (ORC), Cdc6 and Cdt1 facilitate this process, establishing a topological link between eac...

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Detalles Bibliográficos
Autores principales: Ticau, Simina, Friedman, Larry J., Champasa, Kanokwan, Corrêa, Ivan R., Gelles, Jeff, Bell, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336523/
https://www.ncbi.nlm.nih.gov/pubmed/28191892
http://dx.doi.org/10.1038/nsmb.3375

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