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Mechanism and Timing of Mcm2–7 Ring Closure During DNA Replication Origin Licensing
Opening and closing of two ring-shaped Mcm2–7 DNA helicases is necessary to license eukaryotic origins of replication although the mechanisms controlling these events are unclear. The origin-recognition complex (ORC), Cdc6 and Cdt1 facilitate this process, establishing a topological link between eac...
Autores principales: | Ticau, Simina, Friedman, Larry J., Champasa, Kanokwan, Corrêa, Ivan R., Gelles, Jeff, Bell, Stephen P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336523/ https://www.ncbi.nlm.nih.gov/pubmed/28191892 http://dx.doi.org/10.1038/nsmb.3375 |
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