Cargando…
Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass
BACKGROUND: This study aimed to compare myocardial protective effects of anaesthesia with intravenous infusion of propofol versus inhalation of sevoflurane in patients undergoing heart valve replacement surgery with cardiopulmonary bypass. METHODS: Seventy-six patients undergoing valve replacement w...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336653/ https://www.ncbi.nlm.nih.gov/pubmed/28259141 http://dx.doi.org/10.1186/s12871-017-0326-2 |
_version_ | 1782512231590658048 |
---|---|
author | Yang, Xiao-Lin Wang, Dan Zhang, Guo-Yuan Guo, Xiao-Lan |
author_facet | Yang, Xiao-Lin Wang, Dan Zhang, Guo-Yuan Guo, Xiao-Lan |
author_sort | Yang, Xiao-Lin |
collection | PubMed |
description | BACKGROUND: This study aimed to compare myocardial protective effects of anaesthesia with intravenous infusion of propofol versus inhalation of sevoflurane in patients undergoing heart valve replacement surgery with cardiopulmonary bypass. METHODS: Seventy-six patients undergoing valve replacement with cardiopulmonary bypass were randomly assigned to propofol or sevoflurane anesthesia during the surgery, respectively. For assessing myocardial injury, cardiac troponin I (cTnI) and creatine kinase isozyme (CK-MB) were determined before induction (T(0)), 0.5 h (T(1)) and 3 h (T(2)) after aortic unclamping, and 24 h (T(3)) and 48 h (T(4)) after surgery. The concentrations of interleukin (IL)-6 and IL-10 as the systemic inflammatory and anti-inflammatory markers were also measured at above time points. RESULTS: In the sevoflurane group, the plasma concentrations of cTnI and CK-MB from T(l) to T(4) and the levels of IL-6 and IL-10 from T(1) to T(2) were lower than those in the propofol group. Moreover, a higher ratio of automatic heart beat recovery and a shorter length of intensive care unit or hospital stay were found in the sevoflurane group comparing with the propofol group. CONCLUSION: Sevoflurane anaesthesia produced more prominent myocardial protection and attenuated inflammatory response than propofol anaesthesia in patients with valve replacement surgery under cardiopulmonary bypass, resulting in shorter ICU and in-hospital stay. RETROSPECTIVE CLINICAL TRIAL REGISTRATION: Identified as ChiCTR-IOR-16009979 at http://www.chictr.org.cn/. |
format | Online Article Text |
id | pubmed-5336653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53366532017-03-07 Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass Yang, Xiao-Lin Wang, Dan Zhang, Guo-Yuan Guo, Xiao-Lan BMC Anesthesiol Research Article BACKGROUND: This study aimed to compare myocardial protective effects of anaesthesia with intravenous infusion of propofol versus inhalation of sevoflurane in patients undergoing heart valve replacement surgery with cardiopulmonary bypass. METHODS: Seventy-six patients undergoing valve replacement with cardiopulmonary bypass were randomly assigned to propofol or sevoflurane anesthesia during the surgery, respectively. For assessing myocardial injury, cardiac troponin I (cTnI) and creatine kinase isozyme (CK-MB) were determined before induction (T(0)), 0.5 h (T(1)) and 3 h (T(2)) after aortic unclamping, and 24 h (T(3)) and 48 h (T(4)) after surgery. The concentrations of interleukin (IL)-6 and IL-10 as the systemic inflammatory and anti-inflammatory markers were also measured at above time points. RESULTS: In the sevoflurane group, the plasma concentrations of cTnI and CK-MB from T(l) to T(4) and the levels of IL-6 and IL-10 from T(1) to T(2) were lower than those in the propofol group. Moreover, a higher ratio of automatic heart beat recovery and a shorter length of intensive care unit or hospital stay were found in the sevoflurane group comparing with the propofol group. CONCLUSION: Sevoflurane anaesthesia produced more prominent myocardial protection and attenuated inflammatory response than propofol anaesthesia in patients with valve replacement surgery under cardiopulmonary bypass, resulting in shorter ICU and in-hospital stay. RETROSPECTIVE CLINICAL TRIAL REGISTRATION: Identified as ChiCTR-IOR-16009979 at http://www.chictr.org.cn/. BioMed Central 2017-03-04 /pmc/articles/PMC5336653/ /pubmed/28259141 http://dx.doi.org/10.1186/s12871-017-0326-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Yang, Xiao-Lin Wang, Dan Zhang, Guo-Yuan Guo, Xiao-Lan Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
title | Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
title_full | Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
title_fullStr | Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
title_full_unstemmed | Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
title_short | Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
title_sort | comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336653/ https://www.ncbi.nlm.nih.gov/pubmed/28259141 http://dx.doi.org/10.1186/s12871-017-0326-2 |
work_keys_str_mv | AT yangxiaolin comparisonofthemyocardialprotectiveeffectofsevofluraneversuspropofolinpatientsundergoingheartvalvereplacementsurgerywithcardiopulmonarybypass AT wangdan comparisonofthemyocardialprotectiveeffectofsevofluraneversuspropofolinpatientsundergoingheartvalvereplacementsurgerywithcardiopulmonarybypass AT zhangguoyuan comparisonofthemyocardialprotectiveeffectofsevofluraneversuspropofolinpatientsundergoingheartvalvereplacementsurgerywithcardiopulmonarybypass AT guoxiaolan comparisonofthemyocardialprotectiveeffectofsevofluraneversuspropofolinpatientsundergoingheartvalvereplacementsurgerywithcardiopulmonarybypass |