Cargando…
Structural basis for potency differences between GDF8 and GDF11
BACKGROUND: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are conflicting studies on the function of GDF11 and wheth...
Autores principales: | Walker, Ryan G., Czepnik, Magdalena, Goebel, Erich J., McCoy, Jason C., Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L., Schang, Gauthier, Bernard, Daniel J., Hinck, Andrew P., Harrison, Craig A., Martinez-Hackert, Erik, Wagers, Amy J., Lee, Richard T., Thompson, Thomas B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336696/ https://www.ncbi.nlm.nih.gov/pubmed/28257634 http://dx.doi.org/10.1186/s12915-017-0350-1 |
Ejemplares similares
-
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle
por: Lian, John, et al.
Publicado: (2023) -
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers
por: Gipson, Gregory R., et al.
Publicado: (2023) -
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice
por: Walker, Ryan G., et al.
Publicado: (2020) -
Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus
por: Goldstein, Jill M., et al.
Publicado: (2019) -
GDF15 and Growth Control
por: Emmerson, Paul J., et al.
Publicado: (2018)