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Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation

OBJECTIVE: Allograft rejection is still an important cause of morbidity and mortality after heart transplantation (HTx). Many techniques in cardiac magnetic resonance imaging (CMR) were investigated to diagnose acute cellular rejection (ACR). However, there is not enough information about late gadol...

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Autores principales: Şimşek, Evrim, Nalbantgil, Sanem, Ceylan, Naim, Zoghi, Mehdi, Kemal, Hatice Soner, Engin, Çağatay, Yağdı, Tahir, Özbaran, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336724/
https://www.ncbi.nlm.nih.gov/pubmed/26467370
http://dx.doi.org/10.5152/AnatolJCardiol.2015.5961
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author Şimşek, Evrim
Nalbantgil, Sanem
Ceylan, Naim
Zoghi, Mehdi
Kemal, Hatice Soner
Engin, Çağatay
Yağdı, Tahir
Özbaran, Mustafa
author_facet Şimşek, Evrim
Nalbantgil, Sanem
Ceylan, Naim
Zoghi, Mehdi
Kemal, Hatice Soner
Engin, Çağatay
Yağdı, Tahir
Özbaran, Mustafa
author_sort Şimşek, Evrim
collection PubMed
description OBJECTIVE: Allograft rejection is still an important cause of morbidity and mortality after heart transplantation (HTx). Many techniques in cardiac magnetic resonance imaging (CMR) were investigated to diagnose acute cellular rejection (ACR). However, there is not enough information about late gadolinium enhancement (LGE) in the myocardium and ACR. METHODS: We prospectively analyzed our consecutive 41 heart transplant recipients who were admitted for routine endomyocardial biopsies. CMR was performed maximum 6 h before the scheduled endomyocardial biopsy. Correlation between LGE in the myocardium and ACR was investigated. RESULTS: Twenty-seven patients showed no rejection, and nine of them had LGE in the myocardium. Fourteen patients had LGE in the left ventricle (LV), and two patients had LGE also in the right ventricle (RV). There was no correlation between LGE and ACR (p=0.879). There was no difference in the left ventricular ejection fraction (LVEF), right ventricular fractional area change (RVFAC), and cardiac ischemic time between the groups (p=0.825, p=0.370, and p=0.419, respectively). LGE in the myocardium could be due to previous rejection episodes; therefore, all patients were retrospectively searched for previous rejection grades and number of episodes. Thirty-eight of the 41 patients had a history of one ACR episode, but none of them had a statistically significant correlation with LGE (for grade 1R, p=0.964 and grade 3R, p=1) There was also no correlation between number of rejection episodes history and LGE. CONCLUSION: LGE is not suitable to detect ACR in heart transplant patients. LGE and the history of ACR have no correlation.
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spelling pubmed-53367242017-06-28 Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation Şimşek, Evrim Nalbantgil, Sanem Ceylan, Naim Zoghi, Mehdi Kemal, Hatice Soner Engin, Çağatay Yağdı, Tahir Özbaran, Mustafa Anatol J Cardiol Original Investigation OBJECTIVE: Allograft rejection is still an important cause of morbidity and mortality after heart transplantation (HTx). Many techniques in cardiac magnetic resonance imaging (CMR) were investigated to diagnose acute cellular rejection (ACR). However, there is not enough information about late gadolinium enhancement (LGE) in the myocardium and ACR. METHODS: We prospectively analyzed our consecutive 41 heart transplant recipients who were admitted for routine endomyocardial biopsies. CMR was performed maximum 6 h before the scheduled endomyocardial biopsy. Correlation between LGE in the myocardium and ACR was investigated. RESULTS: Twenty-seven patients showed no rejection, and nine of them had LGE in the myocardium. Fourteen patients had LGE in the left ventricle (LV), and two patients had LGE also in the right ventricle (RV). There was no correlation between LGE and ACR (p=0.879). There was no difference in the left ventricular ejection fraction (LVEF), right ventricular fractional area change (RVFAC), and cardiac ischemic time between the groups (p=0.825, p=0.370, and p=0.419, respectively). LGE in the myocardium could be due to previous rejection episodes; therefore, all patients were retrospectively searched for previous rejection grades and number of episodes. Thirty-eight of the 41 patients had a history of one ACR episode, but none of them had a statistically significant correlation with LGE (for grade 1R, p=0.964 and grade 3R, p=1) There was also no correlation between number of rejection episodes history and LGE. CONCLUSION: LGE is not suitable to detect ACR in heart transplant patients. LGE and the history of ACR have no correlation. Kare Publishing 2016-02 2015-06-18 /pmc/articles/PMC5336724/ /pubmed/26467370 http://dx.doi.org/10.5152/AnatolJCardiol.2015.5961 Text en Copyright © 2016 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Şimşek, Evrim
Nalbantgil, Sanem
Ceylan, Naim
Zoghi, Mehdi
Kemal, Hatice Soner
Engin, Çağatay
Yağdı, Tahir
Özbaran, Mustafa
Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
title Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
title_full Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
title_fullStr Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
title_full_unstemmed Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
title_short Diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
title_sort diagnostic performance of late gadolinium enhancement in the assessment of acute cellular rejection after heart transplantation
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336724/
https://www.ncbi.nlm.nih.gov/pubmed/26467370
http://dx.doi.org/10.5152/AnatolJCardiol.2015.5961
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