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Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction
OBJECTIVE: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship b...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kare Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336749/ https://www.ncbi.nlm.nih.gov/pubmed/27684517 http://dx.doi.org/10.14744/AnatolJCardiol.2016.7149 |
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author | Ertem, Ahmet Göktuğ Ünal, Sefa Efe, Tolga Han Açar, Burak Yayla, Çağrı Kuyumcu, Mevlüt Serdar Kırbaş, Özgür Köseoğlu, Cemal Akboğa, Mehmet Kadri Yayla, Kadriye Gayretli Gökaslan, Serkan Aydoğdu, Sinan |
author_facet | Ertem, Ahmet Göktuğ Ünal, Sefa Efe, Tolga Han Açar, Burak Yayla, Çağrı Kuyumcu, Mevlüt Serdar Kırbaş, Özgür Köseoğlu, Cemal Akboğa, Mehmet Kadri Yayla, Kadriye Gayretli Gökaslan, Serkan Aydoğdu, Sinan |
author_sort | Ertem, Ahmet Göktuğ |
collection | PubMed |
description | OBJECTIVE: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI. METHODS: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test. RESULTS: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998–1.000; p=0.007). CONCLUSION: Adropin could be an alternative blood sample value for predicting severity of CAD. |
format | Online Article Text |
id | pubmed-5336749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Kare Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-53367492017-06-28 Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction Ertem, Ahmet Göktuğ Ünal, Sefa Efe, Tolga Han Açar, Burak Yayla, Çağrı Kuyumcu, Mevlüt Serdar Kırbaş, Özgür Köseoğlu, Cemal Akboğa, Mehmet Kadri Yayla, Kadriye Gayretli Gökaslan, Serkan Aydoğdu, Sinan Anatol J Cardiol Original Investigation OBJECTIVE: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI. METHODS: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test. RESULTS: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998–1.000; p=0.007). CONCLUSION: Adropin could be an alternative blood sample value for predicting severity of CAD. Kare Publishing 2017-02 2016-09-28 /pmc/articles/PMC5336749/ /pubmed/27684517 http://dx.doi.org/10.14744/AnatolJCardiol.2016.7149 Text en Copyright: © 2017 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Original Investigation Ertem, Ahmet Göktuğ Ünal, Sefa Efe, Tolga Han Açar, Burak Yayla, Çağrı Kuyumcu, Mevlüt Serdar Kırbaş, Özgür Köseoğlu, Cemal Akboğa, Mehmet Kadri Yayla, Kadriye Gayretli Gökaslan, Serkan Aydoğdu, Sinan Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction |
title | Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction |
title_full | Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction |
title_fullStr | Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction |
title_full_unstemmed | Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction |
title_short | Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction |
title_sort | association between serum adropin level and burden of coronary artery disease in patients with non-st elevation myocardial infarction |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336749/ https://www.ncbi.nlm.nih.gov/pubmed/27684517 http://dx.doi.org/10.14744/AnatolJCardiol.2016.7149 |
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