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Hypotensive effect of alpha-lipoic acid after a single administration in rats

OBJECTIVE: The effect of alpha-lipoic acid on blood pressure was investigated many times in chronic studies, but there are no studies on the effect of this compound after a single administration. Alpha-lipoic acid is a drug used in diabetic neuropathy, often in obese patients, to treat hypertension....

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Autores principales: Dudek, Magdalena, Razny, Katarzyna, Bilska-Wilkosz, Anna, Iciek, Malgorzata, Sapa, Jacek, Wlodek, Lidia, Filipek, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336776/
https://www.ncbi.nlm.nih.gov/pubmed/26488376
http://dx.doi.org/10.5152/AnatolJCardiol.2015.6217
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author Dudek, Magdalena
Razny, Katarzyna
Bilska-Wilkosz, Anna
Iciek, Malgorzata
Sapa, Jacek
Wlodek, Lidia
Filipek, Barbara
author_facet Dudek, Magdalena
Razny, Katarzyna
Bilska-Wilkosz, Anna
Iciek, Malgorzata
Sapa, Jacek
Wlodek, Lidia
Filipek, Barbara
author_sort Dudek, Magdalena
collection PubMed
description OBJECTIVE: The effect of alpha-lipoic acid on blood pressure was investigated many times in chronic studies, but there are no studies on the effect of this compound after a single administration. Alpha-lipoic acid is a drug used in diabetic neuropathy, often in obese patients, to treat hypertension. Therefore, knowledge of the potential antihypertensive effect of alpha-lipoic acid even after a single dose and possibly too much pressure reduction is interesting and useful. METHODS: The mechanism of the hypotensive effect of alpha-lipoic acid was examined in normotensive rats in vivo after a single intraperitoneal administration, blood pressure in the left carotid artery of the rats was measured prior to the administration of the compounds (alpha- lipoic acid and/or glibenclamide) and 80 min thereafter. RESULTS: Alpha-lipoic acid at a dosage of 50 mg/kg b.w. i.p. significantly decreased the blood pressure from the 50(th) min after drug administration. This cardiovascular effect of this compound was reversed by glibenclamide, a selective K(ATP) blocker. Glibenclamide alone at this dose did not significantly affect the blood pressure. Statistical significance was evaluated using two-way ANOVA. CONCLUSION: This suggests that alpha-lipoic acid affects ATP-dependent potassium channels. It is possible that this is an indirect effect of hydrogen sulfide because alpha-lipoic acid can increase its concentration. The results obtained in this study are very important because the patients taking alpha-lipoic acid may be treated for co-existing hypertension. Therefore, the possibility of blood pressure lowering by alpha-lipoic acid should be taken into account, although it does not lead to excessive orthostatic hypotension.
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spelling pubmed-53367762017-06-28 Hypotensive effect of alpha-lipoic acid after a single administration in rats Dudek, Magdalena Razny, Katarzyna Bilska-Wilkosz, Anna Iciek, Malgorzata Sapa, Jacek Wlodek, Lidia Filipek, Barbara Anatol J Cardiol Original Investigation OBJECTIVE: The effect of alpha-lipoic acid on blood pressure was investigated many times in chronic studies, but there are no studies on the effect of this compound after a single administration. Alpha-lipoic acid is a drug used in diabetic neuropathy, often in obese patients, to treat hypertension. Therefore, knowledge of the potential antihypertensive effect of alpha-lipoic acid even after a single dose and possibly too much pressure reduction is interesting and useful. METHODS: The mechanism of the hypotensive effect of alpha-lipoic acid was examined in normotensive rats in vivo after a single intraperitoneal administration, blood pressure in the left carotid artery of the rats was measured prior to the administration of the compounds (alpha- lipoic acid and/or glibenclamide) and 80 min thereafter. RESULTS: Alpha-lipoic acid at a dosage of 50 mg/kg b.w. i.p. significantly decreased the blood pressure from the 50(th) min after drug administration. This cardiovascular effect of this compound was reversed by glibenclamide, a selective K(ATP) blocker. Glibenclamide alone at this dose did not significantly affect the blood pressure. Statistical significance was evaluated using two-way ANOVA. CONCLUSION: This suggests that alpha-lipoic acid affects ATP-dependent potassium channels. It is possible that this is an indirect effect of hydrogen sulfide because alpha-lipoic acid can increase its concentration. The results obtained in this study are very important because the patients taking alpha-lipoic acid may be treated for co-existing hypertension. Therefore, the possibility of blood pressure lowering by alpha-lipoic acid should be taken into account, although it does not lead to excessive orthostatic hypotension. Kare Publishing 2016-05 2015-06-30 /pmc/articles/PMC5336776/ /pubmed/26488376 http://dx.doi.org/10.5152/AnatolJCardiol.2015.6217 Text en Copyright © 2016 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Dudek, Magdalena
Razny, Katarzyna
Bilska-Wilkosz, Anna
Iciek, Malgorzata
Sapa, Jacek
Wlodek, Lidia
Filipek, Barbara
Hypotensive effect of alpha-lipoic acid after a single administration in rats
title Hypotensive effect of alpha-lipoic acid after a single administration in rats
title_full Hypotensive effect of alpha-lipoic acid after a single administration in rats
title_fullStr Hypotensive effect of alpha-lipoic acid after a single administration in rats
title_full_unstemmed Hypotensive effect of alpha-lipoic acid after a single administration in rats
title_short Hypotensive effect of alpha-lipoic acid after a single administration in rats
title_sort hypotensive effect of alpha-lipoic acid after a single administration in rats
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336776/
https://www.ncbi.nlm.nih.gov/pubmed/26488376
http://dx.doi.org/10.5152/AnatolJCardiol.2015.6217
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