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Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome

OBJECTIVE: Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome (PCOS). Heart rate variability (HRV) and heart rate turbulence (HRT) are used in assessing cardiac autonomic functions. The goal of this study was to compare the cardiac autonomic functions in patients wi...

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Autores principales: Özkeçeci, Gülay, Ünlü, Bekir Serdar, Dursun, Hüseyin, Akçi, Önder, Köken, Gülengül, Onrat, Ersel, Avşar, Alaettin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336779/
https://www.ncbi.nlm.nih.gov/pubmed/26488379
http://dx.doi.org/10.5152/AnatolJCardiol.2015.6307
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author Özkeçeci, Gülay
Ünlü, Bekir Serdar
Dursun, Hüseyin
Akçi, Önder
Köken, Gülengül
Onrat, Ersel
Avşar, Alaettin
author_facet Özkeçeci, Gülay
Ünlü, Bekir Serdar
Dursun, Hüseyin
Akçi, Önder
Köken, Gülengül
Onrat, Ersel
Avşar, Alaettin
author_sort Özkeçeci, Gülay
collection PubMed
description OBJECTIVE: Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome (PCOS). Heart rate variability (HRV) and heart rate turbulence (HRT) are used in assessing cardiac autonomic functions. The goal of this study was to compare the cardiac autonomic functions in patients with PCOS and healthy controls. To our knowledge, this is the first study evaluating cardiac autonomic functions in patients with PCOS with respect to both HRV and HRT. METHODS: Twenty-three patients with PCOS (mean age 22.8±3.9 years) and 25 healthy female volunteers who were matched for age and body mass index (BMI) (mean age 23.5±6.2 years) were enrolled in this as case-control study. Twenty-four hour ambulatory electrocardiogram recordings of all participants were taken using Pathfinder software. The time domain parameters of HRV and HRT, including turbulence onset (TO) and turbulence slope, were calculated. Diagnosis of PCOS was made with physical and laboratory findings of hirsutism or biochemical hyperandrogenism and chronic anovulation. Diabetes mellitus, other hormon disorders or hormon therapy, pregnancy, atrial fibrilation, obesite, chronic diseases, disorders of the autonomic nervous system, a history of drug use affecting the autonomic nervous system were excluded. RESULTS: There were no significant differences in HRV and HRT parameters between the two groups. Cardiovascular risk factors, such as BMI, blood pressure, fasting blood glucose, and lipid parameters, were also similar. Triangular index measure of HRV was negatively correlated with high density lipoprotein cholesterol levels (r=-0.47, p<0.05), while age and BMI were significantly correlated with TO (r=0.31 and 0.47, respectively; p<0.05 for all). CONCLUSION: Cardiac autonomic functions were not found to be altered in patients with PCOS in comparison with healthy controls. These results may be explained with the absence of concomitant cardiovascular risk factors with the patients being in the early stage of the disease.
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spelling pubmed-53367792017-06-28 Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome Özkeçeci, Gülay Ünlü, Bekir Serdar Dursun, Hüseyin Akçi, Önder Köken, Gülengül Onrat, Ersel Avşar, Alaettin Anatol J Cardiol Original Investigation OBJECTIVE: Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome (PCOS). Heart rate variability (HRV) and heart rate turbulence (HRT) are used in assessing cardiac autonomic functions. The goal of this study was to compare the cardiac autonomic functions in patients with PCOS and healthy controls. To our knowledge, this is the first study evaluating cardiac autonomic functions in patients with PCOS with respect to both HRV and HRT. METHODS: Twenty-three patients with PCOS (mean age 22.8±3.9 years) and 25 healthy female volunteers who were matched for age and body mass index (BMI) (mean age 23.5±6.2 years) were enrolled in this as case-control study. Twenty-four hour ambulatory electrocardiogram recordings of all participants were taken using Pathfinder software. The time domain parameters of HRV and HRT, including turbulence onset (TO) and turbulence slope, were calculated. Diagnosis of PCOS was made with physical and laboratory findings of hirsutism or biochemical hyperandrogenism and chronic anovulation. Diabetes mellitus, other hormon disorders or hormon therapy, pregnancy, atrial fibrilation, obesite, chronic diseases, disorders of the autonomic nervous system, a history of drug use affecting the autonomic nervous system were excluded. RESULTS: There were no significant differences in HRV and HRT parameters between the two groups. Cardiovascular risk factors, such as BMI, blood pressure, fasting blood glucose, and lipid parameters, were also similar. Triangular index measure of HRV was negatively correlated with high density lipoprotein cholesterol levels (r=-0.47, p<0.05), while age and BMI were significantly correlated with TO (r=0.31 and 0.47, respectively; p<0.05 for all). CONCLUSION: Cardiac autonomic functions were not found to be altered in patients with PCOS in comparison with healthy controls. These results may be explained with the absence of concomitant cardiovascular risk factors with the patients being in the early stage of the disease. Kare Publishing 2016-05 2015-06-18 /pmc/articles/PMC5336779/ /pubmed/26488379 http://dx.doi.org/10.5152/AnatolJCardiol.2015.6307 Text en Copyright © 2016 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Özkeçeci, Gülay
Ünlü, Bekir Serdar
Dursun, Hüseyin
Akçi, Önder
Köken, Gülengül
Onrat, Ersel
Avşar, Alaettin
Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
title Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
title_full Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
title_fullStr Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
title_full_unstemmed Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
title_short Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
title_sort heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336779/
https://www.ncbi.nlm.nih.gov/pubmed/26488379
http://dx.doi.org/10.5152/AnatolJCardiol.2015.6307
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