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The association between platelet/lymphocyte ratio and coronary artery disease severity
OBJECTIVE: In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in coronary artery disease (CAD). METHODS: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gens...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kare Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336865/ https://www.ncbi.nlm.nih.gov/pubmed/25550173 http://dx.doi.org/10.5152/akd.2014.5565 |
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author | Yüksel, Murat Yıldız, Abdulkadir Oylumlu, Mustafa Akyüz, Abdurrahman Aydın, Mesut Kaya, Hasan Acet, Halit Polat, Nihat Bilik, Mehmet Zihni Alan, Sait |
author_facet | Yüksel, Murat Yıldız, Abdulkadir Oylumlu, Mustafa Akyüz, Abdurrahman Aydın, Mesut Kaya, Hasan Acet, Halit Polat, Nihat Bilik, Mehmet Zihni Alan, Sait |
author_sort | Yüksel, Murat |
collection | PubMed |
description | OBJECTIVE: In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in coronary artery disease (CAD). METHODS: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gensini score, which indicates the severity of atherosclerosis, was calculated for all of the patients. Patients with CAD were categorized as mild and severe atherosclerosis, according to their Gensini score. Eighty patients with normal coronary arteries formed the control group. Mean PLR values of the three study groups were compared. Also, PLR value was tested for whether it showed a positive correlation with Gensini score. RESULTS: The mean PLR of the severe atherosclerosis group was significantly higher than that of the mild atherosclerosis and controls groups (p<0.001). Also, PLR was positively correlated with Gensini score in CAD patients. A cut-off value of 111 for PLR predicted severe atherosclerosis with 61% sensitivity and 59% specificity. Pre-procedural PLR level was found to be independently associated with Gensini score, together with WBC, age, and low HDL level, in the multivariate analysis. CONCLUSION: Our study suggests that high PLR appears to be additive to conventional risk factors and commonly used biomarkers in predicting severe atherosclerosis. |
format | Online Article Text |
id | pubmed-5336865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Kare Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-53368652017-06-28 The association between platelet/lymphocyte ratio and coronary artery disease severity Yüksel, Murat Yıldız, Abdulkadir Oylumlu, Mustafa Akyüz, Abdurrahman Aydın, Mesut Kaya, Hasan Acet, Halit Polat, Nihat Bilik, Mehmet Zihni Alan, Sait Anatol J Cardiol Original Investigation OBJECTIVE: In this study, we aimed to explore the association between platelet-to-lymphocyte ratio (PLR) and the severity of atherosclerosis in coronary artery disease (CAD). METHODS: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. Gensini score, which indicates the severity of atherosclerosis, was calculated for all of the patients. Patients with CAD were categorized as mild and severe atherosclerosis, according to their Gensini score. Eighty patients with normal coronary arteries formed the control group. Mean PLR values of the three study groups were compared. Also, PLR value was tested for whether it showed a positive correlation with Gensini score. RESULTS: The mean PLR of the severe atherosclerosis group was significantly higher than that of the mild atherosclerosis and controls groups (p<0.001). Also, PLR was positively correlated with Gensini score in CAD patients. A cut-off value of 111 for PLR predicted severe atherosclerosis with 61% sensitivity and 59% specificity. Pre-procedural PLR level was found to be independently associated with Gensini score, together with WBC, age, and low HDL level, in the multivariate analysis. CONCLUSION: Our study suggests that high PLR appears to be additive to conventional risk factors and commonly used biomarkers in predicting severe atherosclerosis. Kare Publishing 2016-08 2014-07-11 /pmc/articles/PMC5336865/ /pubmed/25550173 http://dx.doi.org/10.5152/akd.2014.5565 Text en Copyright © 2015 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Original Investigation Yüksel, Murat Yıldız, Abdulkadir Oylumlu, Mustafa Akyüz, Abdurrahman Aydın, Mesut Kaya, Hasan Acet, Halit Polat, Nihat Bilik, Mehmet Zihni Alan, Sait The association between platelet/lymphocyte ratio and coronary artery disease severity |
title | The association between platelet/lymphocyte ratio and coronary artery disease severity |
title_full | The association between platelet/lymphocyte ratio and coronary artery disease severity |
title_fullStr | The association between platelet/lymphocyte ratio and coronary artery disease severity |
title_full_unstemmed | The association between platelet/lymphocyte ratio and coronary artery disease severity |
title_short | The association between platelet/lymphocyte ratio and coronary artery disease severity |
title_sort | association between platelet/lymphocyte ratio and coronary artery disease severity |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336865/ https://www.ncbi.nlm.nih.gov/pubmed/25550173 http://dx.doi.org/10.5152/akd.2014.5565 |
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