Relationship between mean platelet volume and morning blood pressure surge in newly diagnosed hypertensive patients

OBJECTIVE: Morning blood pressure surge (MBPS) is an independent predictor of atherothrombotic cardiovascular events in hypertensive patients. There is evidence from studies supporting the validity of mean platelet volume (MPV) as a marker of vascular risk and predictor of thrombotic complications. The aim of this study is to investigate the relationship between MPV and MBPS in hypertensive patients. METHODS: Measurements were obtained from 298 patients with newly diagnosed essential hypertension (Mean age 51.9±11.7 years). The patients were divided into two groups (MPV(low) group; <10.8 fL, MPV(high) group; ≥10.8 fL). The MBPS was calculated as mean systolic BP during the 2 hours after awaking minus the mean systolic BP during the 1 hour that included the lowest sleep BP. RESULTS: MPV was independently associated with MBPS (β=0.554, p<0.001) and hs-CRP level (β=0.286, p<0.001). CONCLUSION: Finally, higher MPV values related to enhanced MBPS which are associated with atherothrombotic cardiovascular events.