Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with...

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Autores principales: Doboszewska, Urszula, Wlaź, Piotr, Nowak, Gabriel, Radziwoń-Zaleska, Maria, Cui, Ranji, Młyniec, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337390/
https://www.ncbi.nlm.nih.gov/pubmed/28299207
http://dx.doi.org/10.1155/2017/3682752
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author Doboszewska, Urszula
Wlaź, Piotr
Nowak, Gabriel
Radziwoń-Zaleska, Maria
Cui, Ranji
Młyniec, Katarzyna
author_facet Doboszewska, Urszula
Wlaź, Piotr
Nowak, Gabriel
Radziwoń-Zaleska, Maria
Cui, Ranji
Młyniec, Katarzyna
author_sort Doboszewska, Urszula
collection PubMed
description Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.
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spelling pubmed-53373902017-03-15 Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity Doboszewska, Urszula Wlaź, Piotr Nowak, Gabriel Radziwoń-Zaleska, Maria Cui, Ranji Młyniec, Katarzyna Neural Plast Review Article Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity. Hindawi Publishing Corporation 2017 2017-02-19 /pmc/articles/PMC5337390/ /pubmed/28299207 http://dx.doi.org/10.1155/2017/3682752 Text en Copyright © 2017 Urszula Doboszewska et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Doboszewska, Urszula
Wlaź, Piotr
Nowak, Gabriel
Radziwoń-Zaleska, Maria
Cui, Ranji
Młyniec, Katarzyna
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
title Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
title_full Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
title_fullStr Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
title_full_unstemmed Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
title_short Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
title_sort zinc in the monoaminergic theory of depression: its relationship to neural plasticity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337390/
https://www.ncbi.nlm.nih.gov/pubmed/28299207
http://dx.doi.org/10.1155/2017/3682752
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