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Reactivation of HIV-1 proviruses in immune-compromised mice engrafted with human VOA-negative CD4+ T cells

BACKGROUND: HIV-1 infection remains incurable on antiretroviral therapy (ART) due to virus latency. To date, enhanced co-culture assays, including viral outgrowth assays (VOA), are commonly used to measure HIV-1 latent reservoirs and evaluate latency-reversing agents (LRAs). However, VOA can only re...

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Detalles Bibliográficos
Autores principales:	Yuan, Zhe, Kang, Guobin, Lu, Wuxun, Li, Qingsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mediscript Ltd 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337423/ https://www.ncbi.nlm.nih.gov/pubmed/28275460

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