Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome

This case report discusses the clinical indication for immunosuppressants in patients with idiopathic membranous nephropathy (IMN). Because this disease occasionally shows spontaneous remission, it is necessary to determine the predictive values for a therapeutic effect in order to provide appropria...

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Autores principales: Tanaka, Atsushi, Nakamura, Tsukasa, Sato, Eiichi, Ueda, Yoshihiko, Node, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337466/
https://www.ncbi.nlm.nih.gov/pubmed/28090051
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author Tanaka, Atsushi
Nakamura, Tsukasa
Sato, Eiichi
Ueda, Yoshihiko
Node, Koichi
author_facet Tanaka, Atsushi
Nakamura, Tsukasa
Sato, Eiichi
Ueda, Yoshihiko
Node, Koichi
author_sort Tanaka, Atsushi
collection PubMed
description This case report discusses the clinical indication for immunosuppressants in patients with idiopathic membranous nephropathy (IMN). Because this disease occasionally shows spontaneous remission, it is necessary to determine the predictive values for a therapeutic effect in order to provide appropriate treatment. Two distinct cases described herein illustrate the different effects of tolvaptan in responders and non-responders, according to the pre-treatment levels of AQP-2 immunostaining in the samples from renal biopsy and urinary levels of AQP-2 and osmolality, suggesting that these values may be useful predictors of response to tolvaptan in patients with nephrotic IMN.
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spelling pubmed-53374662017-03-08 Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome Tanaka, Atsushi Nakamura, Tsukasa Sato, Eiichi Ueda, Yoshihiko Node, Koichi Intern Med Case Report This case report discusses the clinical indication for immunosuppressants in patients with idiopathic membranous nephropathy (IMN). Because this disease occasionally shows spontaneous remission, it is necessary to determine the predictive values for a therapeutic effect in order to provide appropriate treatment. Two distinct cases described herein illustrate the different effects of tolvaptan in responders and non-responders, according to the pre-treatment levels of AQP-2 immunostaining in the samples from renal biopsy and urinary levels of AQP-2 and osmolality, suggesting that these values may be useful predictors of response to tolvaptan in patients with nephrotic IMN. The Japanese Society of Internal Medicine 2017-01-15 /pmc/articles/PMC5337466/ /pubmed/28090051 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tanaka, Atsushi
Nakamura, Tsukasa
Sato, Eiichi
Ueda, Yoshihiko
Node, Koichi
Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome
title Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome
title_full Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome
title_fullStr Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome
title_full_unstemmed Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome
title_short Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome
title_sort different effects of tolvaptan in patients with idiopathic membranous nephropathy with nephrotic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337466/
https://www.ncbi.nlm.nih.gov/pubmed/28090051
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