A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib

A 39-year-old man treated with dasatinib for chronic myelogenous leukaemia presented to our hospital with haemoptysis, coughing, and dyspnoea. Chest radiography and computed tomography revealed ground-glass opacities and a crazy-paving pattern. Bronchoalveolar lavage was not performed due to serious...

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Autores principales: Sakoda, Yoritake, Arimori, Yojiro, Ueno, Masakatsu, Matsumoto, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337468/
https://www.ncbi.nlm.nih.gov/pubmed/28090053
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author Sakoda, Yoritake
Arimori, Yojiro
Ueno, Masakatsu
Matsumoto, Takafumi
author_facet Sakoda, Yoritake
Arimori, Yojiro
Ueno, Masakatsu
Matsumoto, Takafumi
author_sort Sakoda, Yoritake
collection PubMed
description A 39-year-old man treated with dasatinib for chronic myelogenous leukaemia presented to our hospital with haemoptysis, coughing, and dyspnoea. Chest radiography and computed tomography revealed ground-glass opacities and a crazy-paving pattern. Bronchoalveolar lavage was not performed due to serious hypoxemia and bleeding. Significant bleeding from the peripheral bronchi led to a diagnosis of an alveolar haemorrhage. Dasatinib-induced alveolar haemorrhaging was suspected based on the clinical findings. His condition improved immediately after dasatinib withdrawal and initiation of steroid therapy. Reports of alveolar haemorrhaging induced by dasatinib are rare. As such, this is considered an important case.
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spelling pubmed-53374682017-03-08 A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib Sakoda, Yoritake Arimori, Yojiro Ueno, Masakatsu Matsumoto, Takafumi Intern Med Case Report A 39-year-old man treated with dasatinib for chronic myelogenous leukaemia presented to our hospital with haemoptysis, coughing, and dyspnoea. Chest radiography and computed tomography revealed ground-glass opacities and a crazy-paving pattern. Bronchoalveolar lavage was not performed due to serious hypoxemia and bleeding. Significant bleeding from the peripheral bronchi led to a diagnosis of an alveolar haemorrhage. Dasatinib-induced alveolar haemorrhaging was suspected based on the clinical findings. His condition improved immediately after dasatinib withdrawal and initiation of steroid therapy. Reports of alveolar haemorrhaging induced by dasatinib are rare. As such, this is considered an important case. The Japanese Society of Internal Medicine 2017-01-15 /pmc/articles/PMC5337468/ /pubmed/28090053 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sakoda, Yoritake
Arimori, Yojiro
Ueno, Masakatsu
Matsumoto, Takafumi
A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib
title A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib
title_full A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib
title_fullStr A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib
title_full_unstemmed A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib
title_short A Suspected Case of an Alveolar Haemorrhage Caused by Dasatinib
title_sort suspected case of an alveolar haemorrhage caused by dasatinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337468/
https://www.ncbi.nlm.nih.gov/pubmed/28090053
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