A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation. In addition, unlike Arg1, IDO1 is also endowed with non-enzymatic signaling activity in dendriti...

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Detalles Bibliográficos
Autores principales: Mondanelli, Giada, Bianchi, Roberta, Pallotta, Maria Teresa, Orabona, Ciriana, Albini, Elisa, Iacono, Alberta, Belladonna, Maria Laura, Vacca, Carmine, Fallarino, Francesca, Macchiarulo, Antonio, Ugel, Stefano, Bronte, Vincenzo, Gevi, Federica, Zolla, Lello, Verhaar, Auke, Peppelenbosch, Maikel, Mazza, Emilia Maria Cristina, Bicciato, Silvio, Laouar, Yasmina, Santambrogio, Laura, Puccetti, Paolo, Volpi, Claudia, Grohmann, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337620/
https://www.ncbi.nlm.nih.gov/pubmed/28214225
http://dx.doi.org/10.1016/j.immuni.2017.01.005

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