A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats

By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin‐7‐O‐β‐d‐glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophospha...

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Autores principales: Zhang, Li, Gong, Amy G. W., Riaz, Kashif, Deng, Jun Y., Ho, Chih M., Lin, Huang Q., Dong, Tina T. X., Lee, Yi‐Kuen, Tsim, Karl W. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337903/
https://www.ncbi.nlm.nih.gov/pubmed/28286727
http://dx.doi.org/10.1002/2211-5463.12146
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author Zhang, Li
Gong, Amy G. W.
Riaz, Kashif
Deng, Jun Y.
Ho, Chih M.
Lin, Huang Q.
Dong, Tina T. X.
Lee, Yi‐Kuen
Tsim, Karl W. K.
author_facet Zhang, Li
Gong, Amy G. W.
Riaz, Kashif
Deng, Jun Y.
Ho, Chih M.
Lin, Huang Q.
Dong, Tina T. X.
Lee, Yi‐Kuen
Tsim, Karl W. K.
author_sort Zhang, Li
collection PubMed
description By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin‐7‐O‐β‐d‐glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide‐induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.
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spelling pubmed-53379032017-03-10 A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats Zhang, Li Gong, Amy G. W. Riaz, Kashif Deng, Jun Y. Ho, Chih M. Lin, Huang Q. Dong, Tina T. X. Lee, Yi‐Kuen Tsim, Karl W. K. FEBS Open Bio Research Articles By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin‐7‐O‐β‐d‐glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide‐induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia. John Wiley and Sons Inc. 2017-01-28 /pmc/articles/PMC5337903/ /pubmed/28286727 http://dx.doi.org/10.1002/2211-5463.12146 Text en © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhang, Li
Gong, Amy G. W.
Riaz, Kashif
Deng, Jun Y.
Ho, Chih M.
Lin, Huang Q.
Dong, Tina T. X.
Lee, Yi‐Kuen
Tsim, Karl W. K.
A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
title A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
title_full A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
title_fullStr A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
title_full_unstemmed A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
title_short A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
title_sort novel combination of four flavonoids derived from astragali radix relieves the symptoms of cyclophosphamide‐induced anemic rats
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337903/
https://www.ncbi.nlm.nih.gov/pubmed/28286727
http://dx.doi.org/10.1002/2211-5463.12146
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