Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways

Hepatocellular carcinoma (HCC) is one of the most prevalent and malignant cancers with high inter- and intra-tumor heterogeneity. A central common signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1. Pin1 is prevalently o...

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Detalles Bibliográficos
Autores principales: Liao, Xin-Hua, Zhang, Arina Li, Zheng, Min, Li, Mei-Qing, Chen, Champ Peng, Xu, Huijuan, Chu, Qing-Song, Yang, Dayun, Lu, Wenxian, Tsai, Ting-Fen, Liu, Hekun, Zhou, Xiao Zhen, Lu, Kun Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337947/
https://www.ncbi.nlm.nih.gov/pubmed/28262728
http://dx.doi.org/10.1038/srep43639

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