Cargando…

The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma

Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interac...

Descripción completa

Detalles Bibliográficos
Autores principales: Lau, Melisa Y. Z., Dharmage, Shyamali C., Burgess, John A., Win, Aung K., Lowe, Adrian J., Lodge, Caroline, Perret, Jennifer, Hui, Jennie, Thomas, Paul S., Morrison, Stephen, Giles, Graham G., Hopper, John, Abramson, Michael J., Walters, E. Haydn, Matheson, Melanie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337969/
https://www.ncbi.nlm.nih.gov/pubmed/28262750
http://dx.doi.org/10.1038/srep43681
_version_ 1782512477576101888
author Lau, Melisa Y. Z.
Dharmage, Shyamali C.
Burgess, John A.
Win, Aung K.
Lowe, Adrian J.
Lodge, Caroline
Perret, Jennifer
Hui, Jennie
Thomas, Paul S.
Morrison, Stephen
Giles, Graham G.
Hopper, John
Abramson, Michael J.
Walters, E. Haydn
Matheson, Melanie C.
author_facet Lau, Melisa Y. Z.
Dharmage, Shyamali C.
Burgess, John A.
Win, Aung K.
Lowe, Adrian J.
Lodge, Caroline
Perret, Jennifer
Hui, Jennie
Thomas, Paul S.
Morrison, Stephen
Giles, Graham G.
Hopper, John
Abramson, Michael J.
Walters, E. Haydn
Matheson, Melanie C.
author_sort Lau, Melisa Y. Z.
collection PubMed
description Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies of microbial exposure (childhood farm exposure and childhood rural environment). Ten SNPs in four genes (TLR2, TLR4, TLR6, CD14) were genotyped for 1,116 participants from the Tasmanian Longitudinal Health Study (TAHS). Using prospectively collected information, asthma was classified as never, early- (before 13 years) or late-onset (after 13 years). Information on childhood farm exposure/childhood rural environment was collected at baseline. Those with early-onset asthma were more likely to be males, had a family history of allergy and a personal history of childhood atopy. We found significant interaction between TLR6 SNPs and childhood farm exposure. For those with childhood farm exposure, carriers of the TLR6-rs1039559 T-allele (p-interaction = 0.009) and TLR6-rs5743810 C-allele (p-interaction = 0.02) were associated with lower risk of early-onset asthma. We suggest the findings to be interpreted as hypothesis-generating as the interaction effect did not withstand correction for multiple testing. In this large, population-based longitudinal study, we found that the risk of early- and late-onset asthma is differently influenced by the interaction between childhood farming exposure and genetic variations.
format Online
Article
Text
id pubmed-5337969
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-53379692017-03-08 The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma Lau, Melisa Y. Z. Dharmage, Shyamali C. Burgess, John A. Win, Aung K. Lowe, Adrian J. Lodge, Caroline Perret, Jennifer Hui, Jennie Thomas, Paul S. Morrison, Stephen Giles, Graham G. Hopper, John Abramson, Michael J. Walters, E. Haydn Matheson, Melanie C. Sci Rep Article Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies of microbial exposure (childhood farm exposure and childhood rural environment). Ten SNPs in four genes (TLR2, TLR4, TLR6, CD14) were genotyped for 1,116 participants from the Tasmanian Longitudinal Health Study (TAHS). Using prospectively collected information, asthma was classified as never, early- (before 13 years) or late-onset (after 13 years). Information on childhood farm exposure/childhood rural environment was collected at baseline. Those with early-onset asthma were more likely to be males, had a family history of allergy and a personal history of childhood atopy. We found significant interaction between TLR6 SNPs and childhood farm exposure. For those with childhood farm exposure, carriers of the TLR6-rs1039559 T-allele (p-interaction = 0.009) and TLR6-rs5743810 C-allele (p-interaction = 0.02) were associated with lower risk of early-onset asthma. We suggest the findings to be interpreted as hypothesis-generating as the interaction effect did not withstand correction for multiple testing. In this large, population-based longitudinal study, we found that the risk of early- and late-onset asthma is differently influenced by the interaction between childhood farming exposure and genetic variations. Nature Publishing Group 2017-03-06 /pmc/articles/PMC5337969/ /pubmed/28262750 http://dx.doi.org/10.1038/srep43681 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lau, Melisa Y. Z.
Dharmage, Shyamali C.
Burgess, John A.
Win, Aung K.
Lowe, Adrian J.
Lodge, Caroline
Perret, Jennifer
Hui, Jennie
Thomas, Paul S.
Morrison, Stephen
Giles, Graham G.
Hopper, John
Abramson, Michael J.
Walters, E. Haydn
Matheson, Melanie C.
The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma
title The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma
title_full The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma
title_fullStr The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma
title_full_unstemmed The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma
title_short The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma
title_sort interaction between farming/rural environment and tlr2, tlr4, tlr6 and cd14 genetic polymorphisms in relation to early- and late-onset asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337969/
https://www.ncbi.nlm.nih.gov/pubmed/28262750
http://dx.doi.org/10.1038/srep43681
work_keys_str_mv AT laumelisayz theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT dharmageshyamalic theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT burgessjohna theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT winaungk theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT loweadrianj theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT lodgecaroline theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT perretjennifer theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT huijennie theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT thomaspauls theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT morrisonstephen theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT gilesgrahamg theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT hopperjohn theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT abramsonmichaelj theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT waltersehaydn theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT mathesonmelaniec theinteractionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT laumelisayz interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT dharmageshyamalic interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT burgessjohna interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT winaungk interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT loweadrianj interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT lodgecaroline interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT perretjennifer interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT huijennie interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT thomaspauls interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT morrisonstephen interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT gilesgrahamg interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT hopperjohn interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT abramsonmichaelj interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT waltersehaydn interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma
AT mathesonmelaniec interactionbetweenfarmingruralenvironmentandtlr2tlr4tlr6andcd14geneticpolymorphismsinrelationtoearlyandlateonsetasthma