Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis

Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publicatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xiqun, Feng, Danielle, Schwarzschild, Michael A., Gao, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338132/
https://www.ncbi.nlm.nih.gov/pubmed/28275654
http://dx.doi.org/10.1002/acn3.381
_version_ 1782512506027114496
author Chen, Xiqun
Feng, Danielle
Schwarzschild, Michael A.
Gao, Xiang
author_facet Chen, Xiqun
Feng, Danielle
Schwarzschild, Michael A.
Gao, Xiang
author_sort Chen, Xiqun
collection PubMed
description Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
format Online
Article
Text
id pubmed-5338132
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-53381322017-03-08 Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis Chen, Xiqun Feng, Danielle Schwarzschild, Michael A. Gao, Xiang Ann Clin Transl Neurol Brief Communication Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease. John Wiley and Sons Inc. 2017-02-24 /pmc/articles/PMC5338132/ /pubmed/28275654 http://dx.doi.org/10.1002/acn3.381 Text en © 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communication
Chen, Xiqun
Feng, Danielle
Schwarzschild, Michael A.
Gao, Xiang
Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
title Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
title_full Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
title_fullStr Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
title_full_unstemmed Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
title_short Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
title_sort red hair, mc1r variants, and risk for parkinson's disease – a meta‐analysis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338132/
https://www.ncbi.nlm.nih.gov/pubmed/28275654
http://dx.doi.org/10.1002/acn3.381
work_keys_str_mv AT chenxiqun redhairmc1rvariantsandriskforparkinsonsdiseaseametaanalysis
AT fengdanielle redhairmc1rvariantsandriskforparkinsonsdiseaseametaanalysis
AT schwarzschildmichaela redhairmc1rvariantsandriskforparkinsonsdiseaseametaanalysis
AT gaoxiang redhairmc1rvariantsandriskforparkinsonsdiseaseametaanalysis

Ejemplares similares