Neural correlates of adaptive working memory training in a glycogen storage disease type‐IV patient

Glycogen storage disease type‐IV has varied clinical presentations and subtypes. We evaluated a 38‐year‐old man with memory complaints, common symptoms in adult polyglucosan body disease subtype, and investigated cognitive and functional MRI changes associated with two 25‐sessions of adaptive working memory training. He showed improved trained and nontrained working memory up to 6‐months after the training sessions. On functional MRI, he showed increased cortical activation 1–3 months after training, but both increased and decreased activation 6‐months later. Working memory training appears to be beneficial to patients with adult polyglucosan body disease, although continued training may be required to maintain improvements.