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Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine

Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflam...

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Autores principales: Hosseinikia, Roghayeh, Nikbakht, Mohammad Reza, Moghaddam, Ali Asghar, Tajehmiri, Ahmad, Hosseinikia, Mahboobe, Oubari, Farhad, Nikougoftar Zarif, Mahin, Pasdar, Yahya, Mansouri, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338285/
https://www.ncbi.nlm.nih.gov/pubmed/28286618
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author Hosseinikia, Roghayeh
Nikbakht, Mohammad Reza
Moghaddam, Ali Asghar
Tajehmiri, Ahmad
Hosseinikia, Mahboobe
Oubari, Farhad
Nikougoftar Zarif, Mahin
Pasdar, Yahya
Mansouri, Kamran
author_facet Hosseinikia, Roghayeh
Nikbakht, Mohammad Reza
Moghaddam, Ali Asghar
Tajehmiri, Ahmad
Hosseinikia, Mahboobe
Oubari, Farhad
Nikougoftar Zarif, Mahin
Pasdar, Yahya
Mansouri, Kamran
author_sort Hosseinikia, Roghayeh
collection PubMed
description Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic.
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spelling pubmed-53382852017-03-10 Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine Hosseinikia, Roghayeh Nikbakht, Mohammad Reza Moghaddam, Ali Asghar Tajehmiri, Ahmad Hosseinikia, Mahboobe Oubari, Farhad Nikougoftar Zarif, Mahin Pasdar, Yahya Mansouri, Kamran Int J Hematol Oncol Stem Cell Res Review Article Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017-01-01 /pmc/articles/PMC5338285/ /pubmed/28286618 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hosseinikia, Roghayeh
Nikbakht, Mohammad Reza
Moghaddam, Ali Asghar
Tajehmiri, Ahmad
Hosseinikia, Mahboobe
Oubari, Farhad
Nikougoftar Zarif, Mahin
Pasdar, Yahya
Mansouri, Kamran
Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
title Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
title_full Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
title_fullStr Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
title_full_unstemmed Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
title_short Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
title_sort molecular and cellular interactions of allogenic and autologus mesenchymal stem cells with innate and acquired immunity and their role in regenerative medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338285/
https://www.ncbi.nlm.nih.gov/pubmed/28286618
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