Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression

Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers in the world. Elevated glucose metabolism in the availability of oxygen, a phenomenon called the Warburg effect, is important for cancer cell growth. Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeog...

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Detalles Bibliográficos
Autores principales: Yang, Jing, Jin, Xin, Yan, Yuqian, Shao, Yingjie, Pan, Yunqian, Roberts, Lewis R., Zhang, Jun, Huang, Haojie, Jiang, Jingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338333/
https://www.ncbi.nlm.nih.gov/pubmed/28262837
http://dx.doi.org/10.1038/srep43864

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