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SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell death during reperfusion after ischaemia by enhancing Drp1 partitioning to the mitochondrial outer membrane (MOM), which ca...

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Detalles Bibliográficos
Autores principales:	Guo, Chun, Wilkinson, Kevin A., Evans, Ashley J., Rubin, Philip P., Henley, Jeremy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338345/ https://www.ncbi.nlm.nih.gov/pubmed/28262828 http://dx.doi.org/10.1038/srep43811

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