A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations

In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectromet...

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Detalles Bibliográficos
Autores principales: Giddey, Alexander D., de Kock, Elise, Nakedi, Kehilwe C., Garnett, Shaun, Nel, Andrew J. M., Soares, Nelson C., Blackburn, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338346/
https://www.ncbi.nlm.nih.gov/pubmed/28262820
http://dx.doi.org/10.1038/srep43858

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