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A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

The redox co-factor tetrahydrobiopterin (BH(4)) regulates nitric oxide (NO) and reactive oxygen species (ROS) production by endothelial NOS (eNOS) and is an important redox-dependent signalling molecule in the endothelium. Loss of endothelial BH(4) is observed in cardiovascular disease (CVD) states...

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Detalles Bibliográficos
Autores principales:	Bailey, Jade, Shaw, Andrew, Fischer, Roman, Ryan, Brent J., Kessler, Benedikt M., McCullagh, James, Wade-Martins, Richard, Channon, Keith M., Crabtree, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338462/ https://www.ncbi.nlm.nih.gov/pubmed/28104455 http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.012

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