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Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation

PURPOSE: Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in VEGF-induced angiogenesis. The goal of this project was to test the hypothesis that editing genomic VEGFR2 loci using the technology of clustered regularly interspaced palindromic repeats (CRISPR)-associated DNA endo...

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Detalles Bibliográficos
Autores principales:	Huang, Xionggao, Zhou, Guohong, Wu, Wenyi, Ma, Gaoen, D'Amore, Patricia A., Mukai, Shizuo, Lei, Hetian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338630/ https://www.ncbi.nlm.nih.gov/pubmed/28241310 http://dx.doi.org/10.1167/iovs.16-20537

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