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Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials()

It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids...

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Detalles Bibliográficos
Autores principales: Oaks, Brietta M., Young, Rebecca R., Adu-Afarwuah, Seth, Ashorn, Ulla, Jackson, Kristina H., Lartey, Anna, Maleta, Kenneth, Okronipa, Harriet, Sadalaki, John, Baldiviez, Lacey M., Shahab-Ferdows, Setti, Ashorn, Per, Dewey, Kathryn G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Churchill Livingstone 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338685/
https://www.ncbi.nlm.nih.gov/pubmed/28237085
http://dx.doi.org/10.1016/j.plefa.2017.01.007
Descripción
Sumario:It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids (wt%) at 6 months postpartum in a subsample of women enrolled in a randomized controlled trial studying the effects of SQ-LNS on birth outcomes and child growth. Women≤20 wk gestation in Ghana (n=1,320) and Malawi (n=1,391) were assigned to receive daily either: 1) iron-folic acid (pregnancy); 2) multiple micronutrients (pregnancy and lactation); or 3) SQ-LNS (pregnancy and lactation). At 36 wk, plasma ALA levels were higher in those receiving SQ-LNS. SQ-LNS increased breast milk ALA in Ghana but not Malawi. There was no effect on plasma lipids or other selected fatty acids. SQ-LNS may impact plasma and breast milk ALA levels depending on the population.